Factors associated with eclampsia among women who gave birth at Adama hospital medical college, Adama, Ethiopia: A case control study

Factors Associated with Eclampsia

Authors

  • Dereje Tegene a:1:{s:5:"en_US";s:26:"Obstetrics and Gynecology ";}
  • Ephrem Mannekulih
  • Sileshi Garoma

DOI:

https://doi.org/10.69614/ejrh.v17i04.927

Keywords:

Adama, Case control, Determinants, Eclampsia

Abstract

Background: Eclampsia is defined as the occurrences of convulsions and/ or unexplained coma in women with signs and symptoms of preeclampsia. Eclampsia is an obstetric emergency associated with increased maternal and perinatal mortality and morbidity. Identification of predictive factors associated with eclampsia helps caregivers for early identification and prioritization of high-risk pregnant women, which in turn help to develop preventive strategy; in this regard, there is limited information. 

Objective: The study aimed to identify factors associated with Eclampsia among women who gave birth at Adama hospital medical college from January 2019 to December 2021.

Methods and Materials: A case-control study was conducted by reviewing data from a total of 467 patient charts (94 cases and 373 controls). Data were entered into Epi info-7.2 and then exported to SPSS version 20 for analysis. Binary logistic regression analysis was used to model the association between independent variables and Eclampsia. The association between the predictor variables and eclampsia was estimated using an odds ratio with a 95% confidence interval. 

Results: The odds of having eclampsia were 5.3-fold higher among rural residents (AOR = 5.30; 95% CI: 2.98, 9.41). The odds of developing eclampsia were 3.86 fold higher in primiparous (AOR = 3.86; 95% CI: 2.06, 7.24). Women with no antenatal care follow-up had 6.3-fold higher odds of eclampsia (AOR = 6.30; 95% CI: 2.75, 14.46). The odds of eclampsia among anemic pregnant women were 2.3-fold higher (AOR = 2.29; 95% CI: 1.25, 4.18). The odds of eclampsia were 4.7 fold higher in a pregnant woman with a urinary tract infection (AOR = 4.70; 95% CI: 2.41, 9.16).

Conclusion: Being a rural resident, being primigravida, having no antenatal care follow-up, the presence of anemia, and urinary tract infection was independent determinant of eclampsia.

References

References

Abalos E, Cuesta C, Grosso AL, Chou D, Say L. Global and regional estimates of preeclampsia and eclampsia: a systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2013;170(1):1-7.

Gabbe SG, Niebyl JR, Simpson JL, Landon MB, Galan HL, Jauniaux ER, et al. Obstetrics: normal and problem pregnancies e-book: Elsevier Health Sciences; 2016.

Rana S, Karumanchi SA, Levine RJ, Venkatesha S, Rauh-Hain JA, Tamez H, et al. Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia. Hypertension. 2007;50(1):137-42.

Buchbinder A, Sibai BM, Caritis S, MacPherson C, Hauth J, Lindheimer MD, et al. Adverse perinatal outcomes are significantly higher in severe gestational hypertension than in mild preeclampsia. American journal of obstetrics and gynecology. 2002;186(1):66-71.

Barbara L. Hoffman JS, Lisa M. Halvorson, et al. Williams Obstetrics. 2020:1566 - 645.

Fong A, Chau CT, Pan D, Ogunyemi DA. Clinical morbidities, trends, and demographics of eclampsia: a population-based study. American journal of obstetrics and gynecology. 2013;209(3):229. e1-. e7.

Jaatinen N, Ekholm E. Eclampsia in Finland; 2006 to 2010. Acta obstetricia et gynecologica Scandinavica. 2016;95(7):787-92.

Liu S, Joseph K, Liston RM, Bartholomew S, Walker M, León JA, et al. Incidence, risk factors, and associated complications of eclampsia. Obstetrics & Gynecology. 2011;118(5):987-94.

Eke AC, Ezebialu IU, Okafor C. Presentation and outcome of eclampsia at a tertiary center in South East Nigeria–a 6-year review. Hypertension in Pregnancy. 2011;30(2):125-32.

Miguil M, Chekairi A. Eclampsia, study of 342 cases. Hypertension in pregnancy. 2008;27(2):103-11.

Abi-Said D, Annegers JF, Combs-Cantrell D, Frankowski RF, Willmore LJ. Case-control study of the risk factors for eclampsia. American journal of epidemiology. 1995;142(4):437-41.

Agrawal S, Walia GK, Staines-Urias E, Casas JP, Millett C. Prevalence of and risk factors for eclampsia in pregnant women in India. Family Medicine and Community Health. 2017;5(4):225-44.

Abalos E, Cuesta C, Carroli G, Qureshi Z, Widmer M, Vogel J, et al. Pre?eclampsia, eclampsia and adverse maternal and perinatal outcomes: a secondary analysis of the W orld H ealth O rganization Multicountry S urvey on M aternal and N ewborn H ealth. BJOG: An International Journal of Obstetrics & Gynaecology. 2014;121:14-24.

Bugalho A, Bacci A, Bergström S. Risk factors in Mozambican women with eclampsia: a case-referent study. African journal of reproductive health. 2001;5(2):30-5.

Mahran A, Fares H, Elkhateeb R, Ibrahim M, Bahaa H, Sanad A, et al. Risk factors and outcome of patients with eclampsia at a tertiary hospital in Egypt. BMC pregnancy and childbirth. 2017;17(1):1-7.

Coghill AE, Hansen S, Littman AJ. Risk factors for eclampsia: a population-based study in Washington State, 1987–2007. American journal of obstetrics and gynecology. 2011;205(6):553. e1-. e7.

Endeshaw M, Abebe F, Worku S, Menber L, Assress M, Assefa M. Obesity in young age is a risk factor for preeclampsia: a facility based case-control study, northwest Ethiopia. BMC pregnancy and childbirth. 2016;16(1):1-11.

Guerrier G, Oluyide B, Keramarou M, Grais RF. Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria. International journal of women's health. 2013;5:509.

Logan GG, Njoroge PK, Nyabola LO, Mweu MM. Determinants of preeclampsia and eclampsia among women delivering in county hospitals in Nairobi, Kenya. F1000Research. 2020;9:192.

Chames MC, Livingston JC, Ivester TS, Barton JR, Sibai BM. Late postpartum eclampsia: a preventable disease? American journal of obstetrics and gynecology. 2002;186(6):1174-7.

Rudra CB, Williams MA. Monthly variation in preeclampsia prevalence: Washington State, 1987–2001. The journal of maternal-fetal & neonatal medicine. 2005;18(5):319-24.

Grum T, Seifu A, Abay M, Angesom T, Tsegay L. Determinants of pre-eclampsia/Eclampsia among women attending delivery Services in Selected Public Hospitals of Addis Ababa, Ethiopia: a case control study. BMC pregnancy and childbirth. 2017;17(1):1-7.

Morikawa M, Cho K, Yamada T, Yamada T, Sato S, Minakami H. Risk factors for eclampsia in Japan between 2005 and 2009. International Journal of Gynecology & Obstetrics. 2012;117(1):66-8.

Trogstad L, Magnus P, Stoltenberg C. Pre-eclampsia: Risk factors and causal models. Best practice & research Clinical obstetrics & gynaecology. 2011;25(3):329-42.

Meazaw MW, Chojenta C, Muluneh MD, Loxton D. Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa. PloS one. 2020;15(8):e0237600.

Rebahi H, Still ME, Faouzi Y, El Adib AR. Risk factors for eclampsia in pregnant women with preeclampsia and positive neurosensory signs. Turkish journal of obstetrics and gynecology. 2018;15(4):227.

Alves E, Azevedo A, Rodrigues T, Santos AC, Barros H. Impact of risk factors on hypertensive disorders in pregnancy, in primiparae and multiparae. Annals of human biology. 2013;40(5):377-84.

Schneider S, Freerksen N, Maul H, Roehrig S, Fischer B, Hoeft B. Risk groups and maternal-neonatal complications of preeclampsia–current results from the national German Perinatal Quality Registry. 2011.

Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low-and middle-income countries: a WHO secondary analysis. PloS one. 2014;9(3):e91198.

Ali AA, Rayis DA, Abdallah TM, Elbashir MI, Adam I. Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan. BMC research notes. 2011;4(1):1-5.

Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. The lancet. 2006;367(9516):1066-74.

Health FDRoEMo. Maternal death surveillance and response (MDSR) technical guideline. Federal Democratic Republic of Ethiopia Ministry of Health Addis Ababa; 2012.

Legesse T, Abdulahi M, Dirar A. Trends and causes of maternal mortality in Jimma University specialized hospital, Southwest Ethiopia: a matched case–control study. International journal of women's health. 2017;9:307.

Tesfaye G, Loxton D, Chojenta C, Assefa N, Smith R. Magnitude, trends and causes of maternal mortality among reproductive aged women in Kersa health and demographic surveillance system, eastern Ethiopia. BMC women's health. 2018;18(1):1-10.

Thangaratinam S, Langenveld J, Mol BW, Khan KS. Prediction and primary prevention of pre-eclampsia. Best practice & research Clinical obstetrics & gynaecology. 2011;25(4):419-33.

Ajah LO, Ozonu NC, Ezeonu PO, Lawani LO, Obuna JA, Onwe EO. The feto-maternal outcome of preeclampsia with severe features and eclampsia in Abakaliki, South-East Nigeria. Journal of clinical and diagnostic research: JCDR. 2016;10(9):QC18.

Wolde HF, Gonete KA, Akalu TY, Baraki AG, Lakew AM. Factors affecting neonatal mortality in the general population: evidence from the 2016 Ethiopian Demographic and Health Survey (EDHS)—multilevel analysis. BMC research notes. 2019;12(1):1-6.

Duley L, editor The global impact of pre-eclampsia and eclampsia. Seminars in perinatology; 2009: Elsevier.

Dekker GA, Sibai BM. Etiology and pathogenesis of preeclampsia: current concepts. American journal of obstetrics and gynecology. 1998;179(5):1359-75.

Beathe Andersgaard A, Herbst A, Johansen M, Ivarsson A, Ingemarsson I, Langhoff?Roos J, et al. Eclampsia in Scandinavia: incidence, substandard care, and potentially preventable cases. Acta obstetricia et gynecologica Scandinavica. 2006;85(8):929-36.

Ansari MZ, Mueller BA, Krohn MA. Epidemiology of eclampsia. European journal of epidemiology. 1995;11(4):447-51.

Published

2025-10-30

How to Cite

Tegene, D., Mannekulih, E., & Garoma, S. (2025). Factors associated with eclampsia among women who gave birth at Adama hospital medical college, Adama, Ethiopia: A case control study: Factors Associated with Eclampsia. Ethiopian Journal of Reproductive Health, 17(04). https://doi.org/10.69614/ejrh.v17i04.927

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Section

Original Articles

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